meltcalc by E.Schütz and N.v.Ahsen

The ultimate thermodynamic modelling spreadsheet for Excel™

MeltCalc is copyright by:
Ekkehard Schütz and Nicolas von Ahsen.
All rights reserved.

Non-commercial users are invited to download the software now.
The software is available to companies via a non-exclusive license. Further information regarding licensing is available by contacting the authors. Companies are however free to download the software for a 30 day trial. If you wish to use the software beyond the 30 days you must take the appropriate licensing steps. If you do not wish to continue using the software after the trial period, you should remove it from all computers on which you have installed it.
Commercial users or non-commercial users who would like to have the "Professional" version with additional features should follow the "BUY LICENSE" link to the left for further informations and easy on-line registration.

Please read the following disclaimer carefully before proceed with the download, by ordering the Freeware version of MeltCalc© you accept the following terms and conditions:


MeltCalc is © 1999 by Ekkehard Schütz & Nicolas von Ahsen. All rights reserved. No warranties are made as to its correctness or functionality. Usage at your own risk and for research purposes only. Probe sets suggested by this program may not be working properly due to intrinsic properties of the investigated DNA sequence. Please report problems, errors or program bugs in written form to the authors.
The following references describe the MeltCalc program and its first application to hybridization assays on the LightCycler. The first reference should be cited whenever publications report results obtained with MeltCalc. Both references should be cited when the application was on the LightCycler:

(1) Schütz,E. and N.von Ahsen. 1999. Spreadsheet software for thermodynamic melting point prediction of oligonucleotide hybridization with and without mismatches. Biotechniques
(2) von Ahsen,N., M.Oellerich, V.W.Armstrong and E.Schütz. 1999. Application of a thermodynamic nearest-neighbor model to estimate nucleic acid stability and optimize probe design: Prediction of melting points of different mutations of apolipoprotein B 3500 and factor V Leiden with a hybridization probe genotyping assay on the LightCycler. Clin Chem 45:2094-2101.

This software is provided on an "as is" basis. The authors of the software disclaim all warranties relating to this software, whether express or implied, including but not limited to any implied warranties of merchantability or fitness for a particular purpose. Neither the authors nor anyone else who has been involved in the creation, production, or delivery of this software shall be liable for any indirect, consequential, or incidental damages arising out of the use or inability to use such software, even if the authors have been advised of the possibility of such damages or claims. The person using the software bears all risk as to the quality and performance of the software. MeltCalc may not be distributed as part of or for use with any commercial product without express written permission from the authors. The program may not be resold, modified for resale, or used to manufacture commercial products without written approval of the authors.
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